Scientific basis for the use of antioxidants in the treatment of neurodegenerative disorders

Researchers from Nigeria discuss scientific evidence supporting the use of plant-derived antioxidants for the management of neurodegenerative diseases. Their review was published in The Journal of Phytopharmacology.

• Neurodegenerative diseases (NDDs) are ailments that disturb the brain by disrupting the normal functions of neurons.
• Common symptoms of NDDs include problems with stability, inhalation, movement, reflexes, motor skills and heartbeat.
• Studies suggest that NDDs are caused by defective protein degradation and aggregation, oxidative stress, free radical generation, impaired cell energy transformation and mitochondrial dysfunction.
• These events are further supported by the production of pro-inflammatory signaling molecules.
• On the other hand, antioxidants have the ability to boost the body’s defenses and sustain the structural and functional integrity of cells.
• They do so by scavenging free radicals and neutralizing their harmful effects, thus preventing oxidative stress and the onset of inflammation.
• Because of these activities, antioxidants have the potential to prevent NDDs.
• Antioxidants have been shown to promote health by slowing down aging and fighting free radicals.
• Plant-based foods are excellent sources of antioxidants, such as vitamins E and C, flavonoids and polyphenols.
• Vitamin C is a powerful antioxidant that can reduce oxidative damage caused by pollutants, anxiety and poor diet.
• Through its biological activities, vitamin C can help lower the long-term risk of NDDs.
• Although NDDs have no definitive cures at present, scientists believe they can be managed.
• NDD management mainly revolves around reducing their symptoms and increasing the quality of life of patients.
• The use of natural antioxidants, either from diet or supplements, for the management of NDDs offers a variety of health benefits and has become an attractive alternative to conventional medications.

Based on scientific evidence presented by multiple studies, the researchers concluded that consumption of plant-based foods can reduce the risk of neurodegenerative diseases, particularly those caused by neuronal dysfunction.

Journal Reference:

Fadaka AO, Ajiboye BO, Adewale I, Ojo OA, Oyinloye BE, Okesola MA. SIGNIFICANCE OF ANTIOXIDANTS IN THE TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES. The Journal of Phytopharmacology. 20 April 2019;8(2):75-83.